Endocrine Abstracts

Metabolism of the dimeric glycoprotein hormone human chorionic gonadotrophin (hCG) results in the urinary excretion of hCG beta core fragment originating from the beta subunit of hCG (hCGbeta). hCG beta core fragmant retains a certain antigenic shape as well as two metabolically processed N-linked oligosaccharides. Hyperglycosylation of hCGbeta has been used as an indication of aberrant pregnancy especially in malignant disease. We have previously characterised the carbohydrat...